Naphazoline/pheniramine, sold under the brand name Naphcon-A among others, is a combination eye drop used to help the symptoms of allergic conjunctivitis such as from hay fever.[2] It contains naphazoline and pheniramine.[2][1] It is used as an eye drop.[1] Use is not recommended for more than three days.[3]
Side effects may include allergic reactions, eye pain, and dilated pupils.[2][4][3] It is unclear if use in pregnancy is safe.[1] Nephazoline works by resulting in constriction of blood vessels thus decreasing redness while pheniramine works by blocking the effects of histamine to stop itching.[1]
The combination was approved for medical use in the United States in 1994.[5][6][1] It is available over the counter.[5][6][2] In 2017, it was the 203rd most commonly prescribed medication in the United States, with more than two million prescriptions.[7][6]
Medical use
It is administered topically with one to two drops applied to the affected eye(s) up to four times daily.[2]
Adverse effects
- Pupils may become enlarged temporarily
- Overuse may cause more redness
- Those with heart disease, high blood pressure, narrow angle glaucoma or who have urination trouble are discouraged from using the product
- It is recommended to remove contact lenses before use. Use with contact lenses can lead to reduced oxygenation of the underlying cornea
- If infants or children accidentally ingest the drops, it may lead to coma and significant reduction in body temperature. If such ingestion occurs, immediately calling a poison control center is recommended[2]
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